ASSESSMENT OF FRAILTY IN A MULTIPLE MYELOMA (MM) SERIES
(Abstract release date: 05/19/16)
EHA Library. Nikolaou E. 06/09/16; 132852; E1303
Disclosure(s): No Disclosures
Mrs. Eftychia Nikolaou
Contributions
Contributions
Abstract
Abstract: E1303
Type: Eposter Presentation
Background
An increasing number of articles overflow literature concerning the importance of frailty assessment in elderly MM patients in treatment decisions making. Nevertheless, little is known about frailty assessment influence/importance in younger MM patients.
Aims
To assess frailty and investigate its impact in MM patients of any age.
Methods
We studied 409 MM patients, diagnosed and followed –up in our department. Median age was 69 years (31-90) while 55% were males. Twenty-eight percent, 25% and 47% were Durie-Salmon staged 1, 2 and 3 respectively, while 32%, 26% and 42% were ISS staged I, II and III respectively. Twenty-seven percent were asymptomatic (Smoldering MM). MM type was IgG in 66%, IgA in 22% and light-chain in 11% of the population, while 4 patients (1%) were biclonal.Frailty score was estimated following the Geriatric Assessment formula that involves Renal score, Katz andAkpom’s basic activities of daily living (BADL) scale, Lawton and Brody’s instrumental scale (IADL), and the Charlson Comorbidity Index (CCI).Statistical analysis was performed conventionally with SPSS v22.0 software.
Results
Of the 409 patients 24% were fit (frailty score 0), 39% were unfit (frailty score 1) and the rest were frail (14%, 19%, 3% ans 1% with frailty scores 2, 3,4,5 respectively). Frailty score was correlated to OS in the whole cohort (p<0,0001), being more significant in the symptomatic (p<0, 0001) than in the asymptomatic group (p=0,01).In the symptomatic patients, all the parameters examined were significantly correlated to OS [IADL (p<0,0001), BADL (p<0,0001), Renal score (p<0,0001), Performance status (PS) (p<0,0001), ISS (p=0,01), abnormal Ca (p=0,006) and abnormal LDH (p=0,007)]. In the Multiple regression analysis, only ISS (p=0,009), PS (p<0,0001) and level of fitness (p=0,018) preserved their prognostic value. However, in the patient group >70 years, parameters proven statistically important were GFR (p<0,0001) and CCI (p=0,04), while, in the age group >75 years, only CCI was correlated to OS (p=0,002).Finally frailty parameters proved to be more powerful in younger patients (<65 years), for whom GFR (p<0,0001), CCI (p=0,001), IADL (p=0,009) and level of fitness (p=0,002) were correlated to OS.
Conclusion
Intriguingly, frailty score better predicted OS in young MM patients than in elderly ones.
Session topic: E-poster
Keyword(s): Comorbidities, Multiple myeloma, Survival prediction
Type: Eposter Presentation
Background
An increasing number of articles overflow literature concerning the importance of frailty assessment in elderly MM patients in treatment decisions making. Nevertheless, little is known about frailty assessment influence/importance in younger MM patients.
Aims
To assess frailty and investigate its impact in MM patients of any age.
Methods
We studied 409 MM patients, diagnosed and followed –up in our department. Median age was 69 years (31-90) while 55% were males. Twenty-eight percent, 25% and 47% were Durie-Salmon staged 1, 2 and 3 respectively, while 32%, 26% and 42% were ISS staged I, II and III respectively. Twenty-seven percent were asymptomatic (Smoldering MM). MM type was IgG in 66%, IgA in 22% and light-chain in 11% of the population, while 4 patients (1%) were biclonal.Frailty score was estimated following the Geriatric Assessment formula that involves Renal score, Katz andAkpom’s basic activities of daily living (BADL) scale, Lawton and Brody’s instrumental scale (IADL), and the Charlson Comorbidity Index (CCI).Statistical analysis was performed conventionally with SPSS v22.0 software.
Results
Of the 409 patients 24% were fit (frailty score 0), 39% were unfit (frailty score 1) and the rest were frail (14%, 19%, 3% ans 1% with frailty scores 2, 3,4,5 respectively). Frailty score was correlated to OS in the whole cohort (p<0,0001), being more significant in the symptomatic (p<0, 0001) than in the asymptomatic group (p=0,01).In the symptomatic patients, all the parameters examined were significantly correlated to OS [IADL (p<0,0001), BADL (p<0,0001), Renal score (p<0,0001), Performance status (PS) (p<0,0001), ISS (p=0,01), abnormal Ca (p=0,006) and abnormal LDH (p=0,007)]. In the Multiple regression analysis, only ISS (p=0,009), PS (p<0,0001) and level of fitness (p=0,018) preserved their prognostic value. However, in the patient group >70 years, parameters proven statistically important were GFR (p<0,0001) and CCI (p=0,04), while, in the age group >75 years, only CCI was correlated to OS (p=0,002).Finally frailty parameters proved to be more powerful in younger patients (<65 years), for whom GFR (p<0,0001), CCI (p=0,001), IADL (p=0,009) and level of fitness (p=0,002) were correlated to OS.
Conclusion
Intriguingly, frailty score better predicted OS in young MM patients than in elderly ones.
Session topic: E-poster
Keyword(s): Comorbidities, Multiple myeloma, Survival prediction
Abstract: E1303
Type: Eposter Presentation
Background
An increasing number of articles overflow literature concerning the importance of frailty assessment in elderly MM patients in treatment decisions making. Nevertheless, little is known about frailty assessment influence/importance in younger MM patients.
Aims
To assess frailty and investigate its impact in MM patients of any age.
Methods
We studied 409 MM patients, diagnosed and followed –up in our department. Median age was 69 years (31-90) while 55% were males. Twenty-eight percent, 25% and 47% were Durie-Salmon staged 1, 2 and 3 respectively, while 32%, 26% and 42% were ISS staged I, II and III respectively. Twenty-seven percent were asymptomatic (Smoldering MM). MM type was IgG in 66%, IgA in 22% and light-chain in 11% of the population, while 4 patients (1%) were biclonal.Frailty score was estimated following the Geriatric Assessment formula that involves Renal score, Katz andAkpom’s basic activities of daily living (BADL) scale, Lawton and Brody’s instrumental scale (IADL), and the Charlson Comorbidity Index (CCI).Statistical analysis was performed conventionally with SPSS v22.0 software.
Results
Of the 409 patients 24% were fit (frailty score 0), 39% were unfit (frailty score 1) and the rest were frail (14%, 19%, 3% ans 1% with frailty scores 2, 3,4,5 respectively). Frailty score was correlated to OS in the whole cohort (p<0,0001), being more significant in the symptomatic (p<0, 0001) than in the asymptomatic group (p=0,01).In the symptomatic patients, all the parameters examined were significantly correlated to OS [IADL (p<0,0001), BADL (p<0,0001), Renal score (p<0,0001), Performance status (PS) (p<0,0001), ISS (p=0,01), abnormal Ca (p=0,006) and abnormal LDH (p=0,007)]. In the Multiple regression analysis, only ISS (p=0,009), PS (p<0,0001) and level of fitness (p=0,018) preserved their prognostic value. However, in the patient group >70 years, parameters proven statistically important were GFR (p<0,0001) and CCI (p=0,04), while, in the age group >75 years, only CCI was correlated to OS (p=0,002).Finally frailty parameters proved to be more powerful in younger patients (<65 years), for whom GFR (p<0,0001), CCI (p=0,001), IADL (p=0,009) and level of fitness (p=0,002) were correlated to OS.
Conclusion
Intriguingly, frailty score better predicted OS in young MM patients than in elderly ones.
Session topic: E-poster
Keyword(s): Comorbidities, Multiple myeloma, Survival prediction
Type: Eposter Presentation
Background
An increasing number of articles overflow literature concerning the importance of frailty assessment in elderly MM patients in treatment decisions making. Nevertheless, little is known about frailty assessment influence/importance in younger MM patients.
Aims
To assess frailty and investigate its impact in MM patients of any age.
Methods
We studied 409 MM patients, diagnosed and followed –up in our department. Median age was 69 years (31-90) while 55% were males. Twenty-eight percent, 25% and 47% were Durie-Salmon staged 1, 2 and 3 respectively, while 32%, 26% and 42% were ISS staged I, II and III respectively. Twenty-seven percent were asymptomatic (Smoldering MM). MM type was IgG in 66%, IgA in 22% and light-chain in 11% of the population, while 4 patients (1%) were biclonal.Frailty score was estimated following the Geriatric Assessment formula that involves Renal score, Katz andAkpom’s basic activities of daily living (BADL) scale, Lawton and Brody’s instrumental scale (IADL), and the Charlson Comorbidity Index (CCI).Statistical analysis was performed conventionally with SPSS v22.0 software.
Results
Of the 409 patients 24% were fit (frailty score 0), 39% were unfit (frailty score 1) and the rest were frail (14%, 19%, 3% ans 1% with frailty scores 2, 3,4,5 respectively). Frailty score was correlated to OS in the whole cohort (p<0,0001), being more significant in the symptomatic (p<0, 0001) than in the asymptomatic group (p=0,01).In the symptomatic patients, all the parameters examined were significantly correlated to OS [IADL (p<0,0001), BADL (p<0,0001), Renal score (p<0,0001), Performance status (PS) (p<0,0001), ISS (p=0,01), abnormal Ca (p=0,006) and abnormal LDH (p=0,007)]. In the Multiple regression analysis, only ISS (p=0,009), PS (p<0,0001) and level of fitness (p=0,018) preserved their prognostic value. However, in the patient group >70 years, parameters proven statistically important were GFR (p<0,0001) and CCI (p=0,04), while, in the age group >75 years, only CCI was correlated to OS (p=0,002).Finally frailty parameters proved to be more powerful in younger patients (<65 years), for whom GFR (p<0,0001), CCI (p=0,001), IADL (p=0,009) and level of fitness (p=0,002) were correlated to OS.
Conclusion
Intriguingly, frailty score better predicted OS in young MM patients than in elderly ones.
Session topic: E-poster
Keyword(s): Comorbidities, Multiple myeloma, Survival prediction
{{ help_message }}
{{filter}}